Gene expression patterns in developing organisms are established by groups of cross-regulating target genes that are driven by morphogen gradients.As development progresses, morphogen activity is reduced, leaving the emergent pattern without stabilizing positional cues and at risk of rapid deterioration due to the inherently noisy Mains Plug Tops b

Changes in higher order chromatin organisation have been linked to transcriptional regulation; however, little is known about how such organisation alters during embryonic development or how it is regulated by extrinsic signals.Here we analyse changes in chromatin organisation as neural differentiation progresses, exploiting the clear spatial separ